SAMe provides 200 mg of patented, stabilized S-adenosyl-L-methionine per capsule to support biochemical pathways crucial to healthy cellular metabolism. SAMe is an internally produced compound found in every cell of the human body that is involved in more than 100 biochemical reactions. It is naturally synthesized from ATP and the amino acid methionine in the presence of adequate folate and vitamin B12. SAMe is highly concentrated in the liver, adrenal glands, and pineal gland, and is uniformly distributed throughout the brain.

SAMe serves as the body's principal methyl donor, supporting the process of methylation — a continuous cycle involved in the synthesis and healthy functioning of neurotransmitters, phospholipids, proteins, hormones, DNA and RNA, polyamines, and glutathione. These capsules also provide vitamins B6, B12 (as methylcobalamin), and folate (as 5-MTHF), which are nutrient cofactors required for proper SAMe function. Unique acid-resistant encapsulation technology allows intact absorption into the small intestine for superior bioavailability.