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Everyday support
For daily wellness routines.
SAMe Methylation support
SAMe Methylation support
Supportive blend of S-adenosyl-L-methionine (SAMe) and bioavailable B vitamins to help support brain and liver health. May encourage a positive mental outlook, memory, and balanced mood.
Gluten Free Dairy Free Soy Free Vegetarian Non-GMO Vegan
Regular price
$119.99
Regular price
$119.99
Sale price
$129.99
Unit price
per
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SAMe Methylation support
Regular price
$119.99
Regular price
$119.99
Sale price
$129.99
Unit price
per
Benefits
Benefits
200 mg of stabilized SAMe per serving, plus methylated forms of folate and vitamin B12 for enhance bioavailability and methylation support.
• Promotes healthy methylation status
• Supports normal cellular metabolism
• Helps support brain and liver health
• May promote a positive mental outlook, memory, and balanced mood
• Helps supports glutathione and antioxidant status
• Helps supports healthy homocysteine metabolism
Recommended Use: Take 1 capsule per day, preferably on an empty stomach, or as directed by your health-care practitioner.
Just the facts
Just the facts
S-adenosyl-L-methionine (SAMe) is the body's primary methyl donor
SAMe is integral to overall health as it serves as the body’s principal methyl donor — a methyl group is a necessary molecule added to another compound to support its proper function.This process is called methylation, a continuous cycle involved in the synthesis and healthy functioning of neurotransmitters, proteins, hormones, DNA and RNA, and glutathione (the body’s master antioxidant).Supporting SAMe status supports many physiological processes, including brain and liver function.
Designs for Health — Science-Driven Nutrition
Rooted in nutritional science and professional-grade product development, Designs for Health creates thoughtfully formulated supplements with a focus on ingredient quality, research, and precision. From essential vitamins and minerals to specialized nutritional compounds, the brand is committed to providing science-driven nutritional solutions for modern wellness.
KEY INGREDIENTS
Thoughtfully selected nutrients for your overall wellness.
SAMe
Methyl donor support
Vitamin B12
Methylcobalamin
Vitamin B6
B-vitamin cofactors
5-MTHF
Active folate
Ingredients & Supplement Facts
Key nutrients and ingredients per capsule
| Ingredient | Amount | Form |
|---|---|---|
| SAMe | 200 mg | S-Adenosyl-L-Methionine |
| Vitamin B6 | 5 mg | Pyridoxal-5-Phosphate (P-5-P) |
| Folate | 170 mcg | 5-MTHF / [6S]-5-Methyltetrahydrofolate |
| Vitamin B12 | 50 mcg | Methylcobalamin |
Other Ingredients
Cellulose, Microcrystalline Cellulose, Vegetable Stearate, Anhydrous Calcium Chloride, and Calcium Oxide.
Each capsule contains the listed active ingredients and supporting excipients. Please refer to the product label for the most current Supplement Facts and ingredient information.
Suitable for
Support for your needs
Thoughtfully designed support for every stage of your wellness journey.
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Targeted nutrition
For focused nutritional support.
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Healthy habits
For building consistent habits.
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Long-term care
For lasting wellness goals.
Targeted Support for Everyday Wellness
SAMe 170 mg with Vitamin B6, Vitamin B12 and 5-MTHF for comprehensive gutritional support
Methylation Support
Supports normal methylation
pathways and healthy
cellular processes.
Homocysteine Metabolism
Vitamin B6, B12 and 5-MTHF
support normal homocysteine
metabolism.
Mood & Emotional Balance
Provides nutritional supportfor normal mood andemotional balance.
Liver Health Support
Supports healthy liver function and normal metabolic processes.
Joint & Connective Tissue Support
Supports healthy joints and
connective tissue as part
of a balanced diet.
Neurotransmitter Support
Provides nutrients involvedin normal neurotransmitter synthesis.
Our story
Thoughtful wellness, made better
We believe better health starts with better choices, clear information, and products made with purpose.
Made with intention
Every detail is considered to help you feel confident in your daily wellness routine.
01Quality firstCarefully selected ingredients and materials.
02Clear guidanceStraightforward information for informed choices.
03Trusted supportHere to support your everyday wellness journey.
04Made for lifeSimple, practical solutions for real routines.
What This Product Is
SAMe provides 200 mg of patented, stabilized S-adenosyl-L-methionine per capsule to support biochemical pathways crucial to healthy cellular metabolism. SAMe is an internally produced compound found in every cell of the human body that is involved in more than 100 biochemical reactions. It is naturally synthesized from ATP and the amino acid methionine in the presence of adequate folate and vitamin B12. SAMe is highly concentrated in the liver, adrenal glands, and pineal gland, and is uniformly distributed throughout the brain.
SAMe serves as the body's principal methyl donor, supporting the process of methylation — a continuous cycle involved in the synthesis and healthy functioning of neurotransmitters, phospholipids, proteins, hormones, DNA and RNA, polyamines, and glutathione. These capsules also provide vitamins B6, B12 (as methylcobalamin), and folate (as 5-MTHF), which are nutrient cofactors required for proper SAMe function. Unique acid-resistant encapsulation technology allows intact absorption into the small intestine for superior bioavailability.
Frequently asked questions
SAMe is a naturally occurring compound involved in several important processes in the body.
Follow the suggested use on the product label or the guidance of your qualified healthcare professional.
Consult your healthcare professional to determine whether this supplement is appropriate for you.
Review the Supplement Facts panel for the complete ingredient list and amounts.
Store in a cool, dry place and keep the container tightly closed.